He just isnt himself. Our new vet has recommended Simperica, but I wont be giving it to my Collie. Simparica has caused my 12 pound 5 year old Jack Russel Terrior mix to have leg tremors and have trouble walking, jumping, or running. I definitely will not poison her with this garbage anymore. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. I am so upset - I gave it to him last week and he had an accident in the house. She also started drinking excessively, and peeing in the house. I feel like it was a massive overdose. My dog is still having tremors 5 months after taking Simparica. The following day he would not even drink water. But now I tell everyone just be aware that this product does have the potential to cause neurological harm. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. Moreover, the safe use of this product has not been evaluated in breeding, pregnant or lactating dogs. I would not recommend giving Simparica to your pets!!!!! Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. How long did the itching last with your pet. I threw him his ball and he actually was interested in it. Overview. Don't risk the well-being of your beloved dog just because something is more convenient. We rescued another dog. They could either keep her there for observation or I could take her home to observe her. And then when we finally stop for the evening - she crashes. Get the dog moms and dads in your life something unique this year. so what about her puppies I am so worried. We are already close to $2000 in Vet bills not counting the poison we bought her. Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! I will not be giving this medication again! Again our dog had a major seizure in January and we searched for a neurologist ear by. We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. All went well until this morning. Sorry to hear about this happening to so many. He loves the taste of Simparica Trio and it's like a treat for him. Hoping that these side effects dont get worse and subside soon . The main side effect of Simparica Trio is the risk of heartworm disease in dogs. It's not worth the risk of additional seizures or other neurological effects, and it seems that his stumbling and getting tired sooner on walks are likely related. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. So I started searching and came across this blog and my heart just sank. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. Maybe? Sarolaner is also used in combination products for both dogs and cats. She has been the healthiest, happiest dog. She vomited twice and became so lethargic that she couldnt walk. Argh. He was vomiting, had diarrhea, urinating constantly and the very scary part were the uncontrollable tremors. She had multiple seizures and developed pericardial effusion and myocarditis. Called his vet and they gave no information. She continued to have seizures even she was on phenobarbital. Nexgard can cause lethargy and a loss of appetite in dogs. On Jan 4th for the first time. He had been on it for 4-5 months . However, your dog must have a history of negative test results for these diseases. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. Hello! My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. Its crazy to think they dont recover and can die in a few months. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? Has anyone experienced cardiac issues while under anesthesia on this medication? I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. Not wanting to play, shivering, and drinking excessively. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. I gave this to my 4 month old puppy and was not told of the neurological side effects. Them I took him to a vet for check up and to my horror, he has fleas and a tick. The day after administering drug he had two incapacitating seizures. He is a 6 month old Bloodhound so they are always hyper. So, I gave it to him. I am going to try stopping the medication for a month to see if things improve. I used to use revolution but they dont cover ticks as well. We are closely monitoring him. It hurts to see this and infuriating to know these stories are out here and we did not do the research before giving our little guys this poison. There was no clear diagnosis but it was clearly neurological. Now tremors started. She is shaking and panting heavy. Seems like it was directly related to the medication. After reading theses comments I started looking into SIMPARICA TRIO. Weighing your dog regularly will ensure that you are using the correct product size. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. I wish I had read these comments before giving this to my Frenchie. He is 5 months old. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). just gave my one year old dauchund her first dose of simparica My vet didnt tell me, We gave our Yorkie this and she went into seizures later in the daywhat if any thing can be done. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! He had to be put to sleep and Im devastated. Is Simparica only available with a prescription? Hey carol im so sorry to hear about your dog? Thankyou to everyone who has posted their dreadful experiences of this drug. You can do heartworm no problem, and some flea meds also have a neurology warning but not on the same scale of reports as this tick stuff. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. I disagree. Anyway, he prescribed him pain relief for 7 days. Nothing they can do for her she said. We were told the Neurologist would be between $10,000 to $12,000. Be aware! It's been a little over two months since her last dose and feel certain that is what almost killed her. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. This has gone on for about half of the day. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. Why would he knowingly recommend this? During this period coincidentally I have noticed a change in his behaviour. Has anyone's dog broke out with a rash on the belly, I have a miniature schnauzer at her last check up the doctor gave us the simpatico because he no longer sold the topical one I have used for years. Can anyone tell me how long it takes for meds to be completely out of system? My 5 year old Fox Hound isnow drinking lots of water and urinating in the house! (My first warning sign right there). The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. Same as you describe. Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. I honestly think she had a reaction to the medication. Is the added expense worth the trouble to insure your beloved pet? He was in excellent health prior to this incident. Still waiting on the vet and waiting to talk to ASPCA poison control. He has never acted like he was in pain. Itching has decreased immensely. Both of them aren't eating like they were. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. She would constantly twirl in left circles. Another one of our dogs also has had several episodes of suddenly crying as if she is in great pain and also began within a week of administering the poison (please don't call this a medicine, it is a poison intended to kill fleas and other bugs and in this case it can also kill your doggie). Bentlee trusts me an I let him down on this one. The Simparica chewable is a poor choice for dogs with a history of prior seizures. It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. Our 3 mo.old Boston Terrier, 10 lbs, had her first dose of Simparaco yesterday. So new pup goes on garlic tabs-as he growing I'm upping the amount because I wanted him to be protected. The office girl not the vet said if it my dog threw up within one hour after eating her pill - then it is safe to give her another one. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. Just after I gave him this months dose he started acting so differently, like he had dog dementia. This behavior is so inconsistent and confusing. I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. They both got similar issues and this was the only thing they both did. Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). He has no appetite and very little drinking either so hes not using the bathroom much. Simparica trio is a de-worming medication. My dog is on a "health care plan" with my vet. Yep days ago started vomiting and having seizures. Im so terribly sorry about your puppy. Oh Lord, back to finding another vet. I realized it was from the simparica. She has been on our property for four year and has survived everything. It seems to coincide with the monthly dosage. I called my vet but because of Covid they are so behind in appts and would not see him until a month from then. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. He is still not himself, walks very slowly and is definitely not feeling his best. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. I have to turn him around and lead him away. It is recommended to wash your hands after administering this medication. I pray for my baby to be ok and all of you who are in this battle. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. We have been gradually increasing the dose but it hasnt helped. She passed away soon after taking this medication. His immune system is destroying his red blood cells . she has shaking off and on . thank you. If this is a long term issue, I doubt they would be willing to cover all visits in the future. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Saving money sounds great, right? My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. Im still confused. Im switching back to the protection he used before Simparica Trio. Some adverse reactions to Simparica include tremors, decreased awareness of body movement, loss of control over bodily movements, problems blinking, and/or seizures. Omg this is horrible. 12/18/21.. he did experience some diarrhea. Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. 300+ Cute Cat Names for Every Kind of Kitty. Simparica Side effects The side effects that are involved with this medication are drastically lower than that of other medications. Didnt notice anything with first dose. Once she is completely healed I am putting her back on those. Kristine, unfortunately my sweet Dolly passed away on October 9th. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. It's now March 23, he still has falls but not like at first. I only researched it after he started not feeling well, just trusted my vet that this was safe. She was shaking like she was freezing. I gave my 15 year old dog this medicine. I argued with the vet that this is poison and she said why would I give your dog poison? A month later, he was at doggie daycare and we picked him up and he was panting frantically. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. 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